ITM2C Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-17001

Novus Biologicals, part of Bio-Techne
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NBP2-17001
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (97%), Mouse (95%), Porcine (98%), Rat (97%), Sheep (97%). Backed by our 100% Guarantee.

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ITM2C Antibodies »

Product Summary for ITM2C Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human ITM2C. The exact sequence is proprietary.

Reactivity Notes

Chicken (81%).

Localization

Membrane; Single-pass type II membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

30 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for ITM2C Antibody

Western Blot: ITM2C Antibody [NBP2-17001]

Western Blot: ITM2C Antibody [NBP2-17001]

Western Blot: ITM2C Antibody [NBP2-17001] - Sample (30 ug of whole cell lysate) A: Hela 12% SDS PAGE gel, diluted at 1:1000.
Immunohistochemistry-Paraffin: ITM2C Antibody [NBP2-17001]

Immunohistochemistry-Paraffin: ITM2C Antibody [NBP2-17001]

Immunohistochemistry-Paraffin: ITM2C Antibody [NBP2-17001] - MCF7 xenograft, using ITM2C antibody at 1:100 dilution. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.

Applications for ITM2C Antibody

Application
Recommended Usage

Flow Cytometry

Assay dependent

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris-Glycine (pH7), 20% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: ITM2C

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.

Long Name

Integral Membrane Protein 2C

Alternate Names

BRI3, BRICD2C, Cerebral protein 14

Gene Symbol

ITM2C

UniProt

Q9NQX7 (Human)

Additional ITM2C Products

Product Documents for ITM2C Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for ITM2C Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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