JAB1 Antibody (8H8.5)

Novus Biologicals, part of Bio-Techne | Catalog # NB200-312

Novus Biologicals, part of Bio-Techne
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NB200-312
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Key Product Details

Species Reactivity

Human, Mouse, Drosophila

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 8H8.5

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all JAB1 Antibodies »

Product Specifications

Immunogen

The full-length mouse JAB-1 gene expressed in E. coli.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Localization

Nuclear/Cytoplasmic

Specificity

This is specific for JAB-1.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Theoretical MW

38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for JAB1 Antibody (8H8.5)

Western Blot: JAB1 Antibody (8H8.5) [NB200-312]
Western Blot: JAB1 Antibody (8H8.5) [NB200-312]

Western Blot: JAB1 Antibody (8H8.5) [NB200-312]

Western Blot: JAB1 Antibody (8H8.5) [NB200-312] - D10 T cells were lysed in IP buffer (20mM Tris-HCl, pH 7. 5, 50mM NaCl, 50mM NaF, 10mM -glycerophosphate, 1% Triton X-100, 1mM PMSF).
Western Blot: JAB1 Antibody (8H8.5) [NB200-312]

Western Blot: JAB1 Antibody (8H8.5) [NB200-312]

Western Blot: JAB1 Antibody (8H8.5) [NB200-312] - HeLa whole cell lysate

Applications for JAB1 Antibody (8H8.5)

Application
Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: JAB1

JAB-1 is a 38kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the Signalosome, which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.

Long Name

Jun Activation Domain-binding Protein 1

Alternate Names

COPS5, CSN5, MOV-34, SGN5

Gene Symbol

COPS5

Additional JAB1 Products

Product Documents for JAB1 Antibody (8H8.5)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for JAB1 Antibody (8H8.5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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