Kallikrein 6/Neurosin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-06497

Novus Biologicals, part of Bio-Techne
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NBP1-06497
NBP1-06497SS
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Kallikrein 6/Neurosin Antibodies »

Product Specifications

Immunogen

Full length human Kallikrein 6 protein expressed in E. coli. [Swiss-Prot# Q92876]

Reactivity Notes

Immunogen sequence has 85% identity with canine, 82% identity with equine and 80% identity with bovine.

Localization

Cytoplasm

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Kallikrein 6/Neurosin Antibody

Western Blot: Kallikrein 6/Neurosin Antibody [NBP1-06497]

Western Blot: Kallikrein 6/Neurosin Antibody [NBP1-06497]

Western Blot: Kallikrein 6/Neurosin Antibody [NBP1-06497] - Human salivary lysates.
Immunocytochemistry/ Immunofluorescence: Kallikrein 6/Neurosin Antibody [NBP1-06497]

Immunocytochemistry/ Immunofluorescence: Kallikrein 6/Neurosin Antibody [NBP1-06497]

Immunocytochemistry/Immunofluorescence: Kallikrein 6/Neurosin Antibody [NBP1-06497] - Kallikrein 6 antibody was tested in Hek293 cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

Applications for Kallikrein 6/Neurosin Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:20

Western Blot

1:1000
Application Notes
This Kallikrein 6 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen at ~38kDa due to glycosylation. In ICC/IF cytoplasmic staining was observed. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole antisera

Preservative

0.1% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Kallikrein 6/Neurosin

Kallikrein 6 (KLK6 or kallikrein-related peptidase 6) is a serine protease with trypsin-like properties and belongs to family of KLKs that serves multiple physiological functions including blood pressure regulation, semen liquefaction, skin desquamation etc. and have also been known to implicate in several pathological processes such as tumorigenesis/metastasis, angiogenesis, neurological diseases etc. KLK6 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins including fibronectin, laminin, vitronectin as well as collagen. KLK6 exerts degradation mediated prevention of alpha-synuclein polymerization, suggesting its role in synucleinopathies such as Parkinson disease. KLK6 has also been proposed to involve in regulation of axon outgrowth following spinal cord injury and in pathways including inflammation, receptor activation and apoptosis regulation. Expressed at highest levels brain among other normal tissues, KLK6 has been extensively studied in cancer as well as neurodegenerative diseases wherein it has emerged as a novel biomarkers for prognosis, diagnosis and therapeutic intervention.

Alternate Names

KLK6, Neurosin, Protease M, PRSS18, PRSS9, SP59, Zyme

Entrez Gene IDs

5653 (Human)

Gene Symbol

KLK6

UniProt

Q92876

Additional Kallikrein 6/Neurosin Products

Product Documents for Kallikrein 6/Neurosin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Kallikrein 6/Neurosin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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