KCC2/SLC12A5 [p Thr1007] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11949

Novus Biologicals, part of Bio-Techne
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NBP3-11949-25ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Mouse, Rat

Predicted:

Bovine (100%), Human (100%), Porcine (100%), Primate (100%), Sheep (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all KCC2/SLC12A5 Antibodies »

Product Specifications

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr1007 of rat KCC2, conjugated to keyhole limpet hemocyanin (KLH) [UniProt Q63633].

Modification

p Thr1007

Specificity

Specific for endogenous levels of the ~135 kDa KCC2 protein phosphorylated at Thr1007. Immunolabeling is completely eliminated by treatment with lambda-phosphatase.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

135 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for KCC2/SLC12A5 [p Thr1007] Antibody

Western Blot: KCC2/SLC12A5 [p Thr1007] Antibody [NBP3-11949]

Western Blot: KCC2/SLC12A5 [p Thr1007] Antibody [NBP3-11949]

Western Blot: KCC2/SLC12A5 [p Thr 1007] Antibody [NBP3-11949] - Western blot of rat hippocampal lysate showing specific labeling of the ~135 kDa KCC2/SLC12A5 protein phosphorylated at Thr1007 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (lambda-Ptase, 1200 units for 30 min).

Applications for KCC2/SLC12A5 [p Thr1007] Antibody

Application
Recommended Usage

Western Blot

1:1000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10 mM HEPES (pH 7.5), 0.15 M NaCl, 0.1 mg/mL BSA, 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C.

Background: KCC2/SLC12A5

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. (provided by RefSeq)

Long Name

K-Cl Cotransporter 2

Alternate Names

SLC12A5

Gene Symbol

SLC12A5

Additional KCC2/SLC12A5 Products

Product Documents for KCC2/SLC12A5 [p Thr1007] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for KCC2/SLC12A5 [p Thr1007] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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