Kirrel2/NEPH3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-68977

Novus Biologicals, part of Bio-Techne
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NBP2-68977
NBP2-68977-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (91%), Rat (90%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Kirrel2/NEPH3 Antibodies »

Product Summary for Kirrel2/NEPH3 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: EVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Kirrel2/NEPH3 Antibody

Immunocytochemistry/ Immunofluorescence: Kirrel2/NEPH3 Antibody [NBP2-68977]

Immunocytochemistry/ Immunofluorescence: Kirrel2/NEPH3 Antibody [NBP2-68977]

Immunocytochemistry/Immunofluorescence: Kirrel2/NEPH3 Antibody [NBP2-68977] - Staining of human cell line REH shows localization to centrosome. Antibody staining is shown in green.

Applications for Kirrel2/NEPH3 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
ICC/IF Fixation/Permeabilization: PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Kirrel2/NEPH3

Kirrel (kin of irregular chiasm-1-like) proteins, also known as the NEPH (nephrin-like) family, are type I transmembrane glycoproteins within the immunoglobulin superfamily. Kirrel1 (NEPH1), Kirrel2 (NEPH3, Filtrin, NLG-1) and Kirrel3 (NEPH2, kirre) share 34 - 44% amino acid (aa) identity, and all interact with nephrin, podocin and the adaptor molecule ZO-1 (1, 4). All can be found in podocytes of the kidney glomerulus, and play a role in barrier function in the slit diaphragm. (2-6). Kirrel1 can also be found in central nervous system neurons, pancreas and placenta, Kirrel2 in pancreatic islet beta cells, brain and lymph nodes, and Kirrel3 in the brain and bone marrow, typically at sites where nephrin is also expressed.

Long Name

Kin of Irregular Chiasm-like 2, Splice Variant A

Alternate Names

Filtrin, NEPH3, NLG1

Gene Symbol

KIRREL2

Additional Kirrel2/NEPH3 Products

Product Documents for Kirrel2/NEPH3 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Kirrel2/NEPH3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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