KLHL12/C3IP1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-56310

Novus Biologicals, part of Bio-Techne
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NBP2-56310
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all KLHL12/C3IP1 Antibodies »

Product Summary for KLHL12/C3IP1 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: FAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for KLHL12/C3IP1 Antibody

Western Blot: KLHL12/C3IP1 Antibody [NBP2-56310]

Western Blot: KLHL12/C3IP1 Antibody [NBP2-56310]

Western Blot: KLHL12/C3IP1 Antibody [NBP2-56310] - Western blot analysis in human cell line RT-4 and human cell line U-251 MG.
Immunocytochemistry/ Immunofluorescence: KLHL12/C3IP1 Antibody [NBP2-56310]

Immunocytochemistry/ Immunofluorescence: KLHL12/C3IP1 Antibody [NBP2-56310]

Immunocytochemistry/Immunofluorescence: KLHL12/C3IP1 Antibody [NBP2-56310] - Staining of human cell line SiHa shows localization to microtubule organizing center & vesicles.

Applications for KLHL12/C3IP1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Western Blot

0.04-0.4 ug/ml
Application Notes
ICC/IF, Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: KLHL12/C3IP1

Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3. Component of an ubiquitin-protein E3 ligase complex which includes at least CUL3 and KLHL12. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A.

Alternate Names

C3IP1kelch-like protein 12, CUL3-interacting protein 1, DKIR, FLJ27152, kelch-like 12 (Drosophila), kelch-like protein C3IP1

Gene Symbol

KLHL12

Additional KLHL12/C3IP1 Products

Product Documents for KLHL12/C3IP1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for KLHL12/C3IP1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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