KPNA6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-93456

Novus Biologicals, part of Bio-Techne
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NB100-93456
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Porcine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all KPNA6 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-STTGESVITREMVE corresponding to internal region according to NP_036448.1.

Epitope

C-STTGESVITREMVE

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for KPNA6 Antibody

Western Blot: KPNA6 Antibody [NB100-93456]

Western Blot: KPNA6 Antibody [NB100-93456]

Western Blot: KPNA6 Antibody [NB100-93456] - (0.1ug/ml) staining of Human Muscle lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: KPNA6 Antibody [NB100-93456]

Immunohistochemistry-Paraffin: KPNA6 Antibody [NB100-93456]

Immunohistochemistry-Paraffin: KPNA6 Antibody [NB100-93456] - (3.8ug/ml) staining of paraffin embedded Human Adrenal Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for KPNA6 Antibody

Application
Recommended Usage

Immunohistochemistry

3 - 6 ug/ml

Immunohistochemistry-Paraffin

3 - 6 ug/ml

Peptide ELISA

Detection limit 1:128000

Western Blot

0.1 - 0.3 ug/ml
Application Notes
WB: Approx. 60 kDa band observed in human skeletal muscle lysates (calculated MW of 60.0 kDa band according to NP_036448.1). Some minor background is detected and is blocked by the immunizing peptide. We call for caution when used for other assays than WB. IHC-P: Human adrenal gland shows staining of cytoplasm and some nuclear membrane (nuclear pores).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: KPNA6

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq]

Alternate Names

importin alpha 7 subunit, importin subunit alpha-7, importin-alpha-S2, IPOA7FLJ11249, karyopherin alpha 6 (importin alpha 7), Karyopherin subunit alpha-6, KPNA7, MGC17918

Entrez Gene IDs

23633 (Human); 16650 (Mouse); 362607 (Rat)

Gene Symbol

KPNA6

UniProt

NP_036448.1 (Human)

Additional KPNA6 Products

Product Documents for KPNA6 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for KPNA6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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