Ku70/XRCC6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38954

Novus Biologicals, part of Bio-Techne
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NBP2-38954
NBP2-38954-25ul
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human

Predicted:

Mouse (90%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Ku70/XRCC6 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: DVQFKMSHKRIMLFTNEDNPHGNDSAKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLEDLLRKVRAKETR

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Ku70/XRCC6 Antibody

Western Blot: Ku70/XRCC6 Antibody [NBP2-38954]

Western Blot: Ku70/XRCC6 Antibody [NBP2-38954]

Western Blot: Ku70/XRCC6 Antibody [NBP2-38954] - Analysis using Anti-XRCC6 antibody NBP2-38954 (A) shows similar pattern to independent antibody NBP2-38567 (B).
Immunohistochemistry-Paraffin: Ku70/XRCC6 Antibody [NBP2-38954]

Immunohistochemistry-Paraffin: Ku70/XRCC6 Antibody [NBP2-38954]

Immunohistochemistry-Paraffin: Ku70/XRCC6 Antibody [NBP2-38954] - Staining of human cerebral cortex, kidney, skin and testis using Anti-XRCC6 antibody NBP2-38954 (A) shows similar protein distribution across tissues to independent antibody NBP2-38567 (B).
Immunocytochemistry/ Immunofluorescence: Ku70/XRCC6 Antibody [NBP2-38954]

Immunocytochemistry/ Immunofluorescence: Ku70/XRCC6 Antibody [NBP2-38954]

Immunocytochemistry/Immunofluorescence: Ku70/XRCC6 Antibody [NBP2-38954] - Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm. Antibody staining is shown in green.
View 4 more images

Applications for Ku70/XRCC6 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Ku70/XRCC6

The Ku autoantigen is a heterodimer of 70kDa (p70) and ~80kDa (p80) proteins. The p70/p80 dimer is important for function of a 460kDa DNAdependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.

Long Name

Lupus Ku Autoantigen Protein 70

Alternate Names

CTC75, CTCBF, G22P1, ML8, TLAA, XRCC6

Gene Symbol

XRCC6

UniProt

P12956

Additional Ku70/XRCC6 Products

Product Documents for Ku70/XRCC6 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Ku70/XRCC6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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