Ku80, also known as XRCC5, plays a role in many diverse processes including cell signaling, proliferation, DNA repair, replication, transcriptional activation and apoptosis.

As one half of the heterodimer complex Ku, Ku80 is required for proper maintenance of the telomeric C strand. Ku80 also plays a role in DNA repair as an essential subunit of DNA-dependent protein kinase (DNA-PK) that phosphorylates certain transcription factors (Sp1, Oct-1 and p53). The heterodimer Ku binds double stranded DNA breaks for non-homologous end joining repair. Ku mutants are defective in T-DNA integration and over-expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.

Long Name

Lupus Ku Autoantigen Protein 86

Alternate Names

CTC85, G22P2, KARP1, Ku86, KUB2, NFIV, XRCC5

Gene Symbol

XRCC5

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Product Documents for Ku80/XRCC5 Antibody (XRCC5/8093R) [Janelia Fluor® 549]

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Product Specific Notices for Ku80/XRCC5 Antibody (XRCC5/8093R) [Janelia Fluor® 549]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Ku80/XRCC5 Antibody (XRCC5/8093R) [Janelia Fluor® 549]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21133JF549

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Applications for Ku80/XRCC5 Antibody (XRCC5/8093R) [Janelia Fluor® 549]

Immunohistochemistry-Paraffin

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Background: Ku80/XRCC5