Kv4.2 Antibody (5B11B9) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-52497

Novus Biologicals, part of Bio-Techne
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NBP2-52497-0.025mg
NBP2-52497
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Key Product Details

Species Reactivity

Validated:

Human

Applications

CyTOF-ready, ELISA, Flow Cytometry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 5B11B9

Format

BSA Free

Concentration

1 mg/ml

View all Kv4.2 Antibodies »

Product Summary for Kv4.2 Antibody (5B11B9) - BSA Free

Immunogen

Purified recombinant fragment of human Kv4.2 (AA: 27-184) expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

70.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Kv4.2 Antibody (5B11B9) - BSA Free

Western Blot: Kv4.2 Antibody (5B11B9)BSA Free [NBP2-52497]

Western Blot: Kv4.2 Antibody (5B11B9)BSA Free [NBP2-52497]

Western Blot: Kv4.2 Antibody (5B11B9) [NBP2-52497] - Western blot analysis using KCND2 mAb against human KCND2 (AA: 27-184) recombinant protein. (Expected MW is 42.3 kDa)
Flow Cytometry: Kv4.2 Antibody (5B11B9) - BSA Free [NBP2-52497]

Flow Cytometry: Kv4.2 Antibody (5B11B9) - BSA Free [NBP2-52497]

Flow Cytometry: Kv4.2 Antibody (5B11B9) [NBP2-52497] - Analysis of Hela cells using KCND2 mouse mAb (green) and negative control (red).
Western Blot: Kv4.2 Antibody (5B11B9)BSA Free [NBP2-52497]

Western Blot: Kv4.2 Antibody (5B11B9)BSA Free [NBP2-52497]

Western Blot: Kv4.2 Antibody (5B11B9) [NBP2-52497] - Analysis using KCND2 mAb against HEK293 (1) and KCND2 (AA: 27-184)-hIgGFc transfected HEK293 (2) cell lysate.
View 1 more images

Applications for Kv4.2 Antibody (5B11B9) - BSA Free

Application
Recommended Usage

ELISA

1:10000

Flow Cytometry

1:200-1:400

Western Blot

1:500-1:2000
Application Notes
This antibody is Cytof ready.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Kv4.2

Kv4.2, a voltage-gated K+ (Kv) channel subunit, has been suggested to be the key component of the subthreshold A-type K+ currents (I(SA)s) recorded from the specific subcellular compartments of certain CNS neurons (1). A-type channels, encoded by the pore-forming alpha-subunits of the Kv4.x family, are particularly important in regulating membrane excitability in the CNS and the heart. Kv4.2 is a Shal-type potassium channel that passes an A-type current and is localized to dendrites and cell bodies in the hippocampus (2). Deletion of the Kv4.2 gene and a loss of Kv4.2 protein resulted in a specific and near-complete elimination of A-type K+ currents from the apical dendrites of CA1 pyramidal neurons. The absence of dendritic Kv4.2-encoded A-type K+ currents led to an increase of bAP amplitude and an increase of concurrent Ca2+ influx (3).

Alternate Names

potassium voltage-gated channel, Shal-related subfamily, member 2, RK5, voltage-gated potassium channel Kv4.2, voltage-sensitive potassium channel

Gene Symbol

KCND2

Additional Kv4.2 Products

Product Documents for Kv4.2 Antibody (5B11B9) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Kv4.2 Antibody (5B11B9) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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