Kv4.2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87708

Novus Biologicals, part of Bio-Techne
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NBP1-87708
NBP1-87708-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (99%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Kv4.2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: GSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNIVRVSA

Reactivity Notes

Reactivity reported in scientific literature (PMID: 24037343)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Kv4.2 Antibody

Immunohistochemistry-Paraffin: Kv4.2 Antibody [NBP1-87708]

Immunohistochemistry-Paraffin: Kv4.2 Antibody [NBP1-87708]

Immunohistochemistry-Paraffin: Kv4.2 Antibody [NBP1-87708] - Staining of human cerebellum shows strong cytoplasmic positivity in cells of granular layer.

Applications for Kv4.2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Kv4.2

Kv4.2, a voltage-gated K+ (Kv) channel subunit, has been suggested to be the key component of the subthreshold A-type K+ currents (I(SA)s) recorded from the specific subcellular compartments of certain CNS neurons (1). A-type channels, encoded by the pore-forming alpha-subunits of the Kv4.x family, are particularly important in regulating membrane excitability in the CNS and the heart. Kv4.2 is a Shal-type potassium channel that passes an A-type current and is localized to dendrites and cell bodies in the hippocampus (2). Deletion of the Kv4.2 gene and a loss of Kv4.2 protein resulted in a specific and near-complete elimination of A-type K+ currents from the apical dendrites of CA1 pyramidal neurons. The absence of dendritic Kv4.2-encoded A-type K+ currents led to an increase of bAP amplitude and an increase of concurrent Ca2+ influx (3).

Alternate Names

potassium voltage-gated channel, Shal-related subfamily, member 2, RK5, voltage-gated potassium channel Kv4.2, voltage-sensitive potassium channel

Gene Symbol

KCND2

Additional Kv4.2 Products

Product Documents for Kv4.2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Kv4.2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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