Lamin B Receptor Antibody (SR2150)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21681

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21681-100ul
NBP3-21681-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2150

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Lamin B Receptor Antibodies »

Product Summary for Lamin B Receptor Antibody (SR2150)

Immunogen

A synthesized peptide derived from human Lamin B Receptor (Uniprot #: Q14739)

Specificity

Detects endogenous levels of total Lamin B Receptor

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Lamin B Receptor Antibody (SR2150)

Western Blot: Lamin B Receptor Antibody (SR2150) [NBP3-21681] -

Western Blot: Lamin B Receptor Antibody (SR2150) [NBP3-21681] - Western blot analysis using NBP3-21681 in Jurkat cell lysate.

Applications for Lamin B Receptor Antibody (SR2150)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:500

Immunohistochemistry

1:50-1:200

Immunoprecipitation

1:30

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Lamin B Receptor

Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4).

Alternate Names

DHCR14B, FLJ43126, Integral nuclear envelope inner membrane protein, lamin B receptor, lamin-B receptor, LMN2R, MGC9041, PHA

Gene Symbol

LBR

Additional Lamin B Receptor Products

Product Documents for Lamin B Receptor Antibody (SR2150)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Lamin B Receptor Antibody (SR2150)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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