Lamin B Receptor Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-14185

Novus Biologicals, part of Bio-Techne
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NBP2-14185
NBP2-14185-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Lamin B Receptor Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to the amino acids: MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSFRQRKGGSTSSS

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (89%) Use in Mouse reported in scientific literature (PMID:33846535)

Marker

Nuclear Inner Membrane Marke

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Lamin B Receptor Antibody

Immunohistochemistry-Paraffin: Lamin B Receptor Antibody [NBP2-14185]

Immunohistochemistry-Paraffin: Lamin B Receptor Antibody [NBP2-14185]

Immunohistochemistry-Paraffin: Lamin B Receptor Antibody [NBP2-14185] - Analysis in human lymph node and skeletal muscle tissues. Corresponding LBR RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Lamin B Receptor Antibody [NBP2-14185]

Immunohistochemistry-Paraffin: Lamin B Receptor Antibody [NBP2-14185]

Immunohistochemistry-Paraffin: Lamin B Receptor Antibody [NBP2-14185] - Staining of human testis shows strong positivity in nuclear membrane in subset of cells in seminiferous ducts.
Immunohistochemistry-Paraffin: Lamin B Receptor Antibody [NBP2-14185]

Immunohistochemistry-Paraffin: Lamin B Receptor Antibody [NBP2-14185]

Immunohistochemistry-Paraffin: Lamin B Receptor Antibody [NBP2-14185] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
View 2 more images

Applications for Lamin B Receptor Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
Use in Western Blot reported in scientific literature (PMID:33846535) For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Lamin B Receptor

Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4).

Alternate Names

DHCR14B, FLJ43126, Integral nuclear envelope inner membrane protein, lamin B receptor, lamin-B receptor, LMN2R, MGC9041, PHA

Gene Symbol

LBR

Additional Lamin B Receptor Products

Product Documents for Lamin B Receptor Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Lamin B Receptor Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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