LAR/PTPRF Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-75290

Novus Biologicals, part of Bio-Techne
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NB100-75290
NB100-75290-0.025mg
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Chicken

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all LAR Antibodies »

Product Summary for LAR/PTPRF Antibody

Immunogen

The immunogen for this antibody was a sequence from 1151a.a. to 1225a.a. from LAR(a 1897a.a. long protein)

Reactivity Notes

This antibody is reactive against Human, mouse, rat.

Localization

Cytoplasm. Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus.

Specificity

LAR

Clonality

Polyclonal

Host

Chicken

Scientific Data Images for LAR/PTPRF Antibody

Western Blot: LAR/PTPRF Antibody [NB100-75290]

Western Blot: LAR/PTPRF Antibody [NB100-75290]

Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. (anti-PTPRF)

Applications for LAR/PTPRF Antibody

Application
Recommended Usage

Western Blot

1:200 - 1:500
Application Notes
Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2)

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LAR

Leukocyte common antigen-related (LAR) family receptor protein tyrosine phosphatases (LAR-RPTP) bind to liprin-alpha (SYD2) and are implicated in axon guidance. LAR is also involved in the regulation of epithelial cell-cell contacts and in the control of beta-catenin signaling. Increased LAR expression is found in the insulin-responsive tissue of obese insulin-resistant individuals and may contribute to the pathogenesis of insulin resistance. LAR is a receptor-type PTP and possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. The extracellular region contains three Ig-like domains, and nine domains similar to that of neural-cell adhesion molecule. Several isoforms of LAR have been reported. Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).. The first PTPase domain has enzymatic activity. while the second one seems to affect the substrate specificity of the first one.

Long Name

Leukocyte Antigen-Related Tyrosine Phosphatase

Alternate Names

PTPRF

Entrez Gene IDs

5792 (Human); 19268 (Mouse); 360406 (Rat)

Gene Symbol

PTPRF

UniProt

P10586 (Human)

Additional LAR Products

Product Documents for LAR/PTPRF Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LAR/PTPRF Antibody

Chicken products cannot be exported to Canada.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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