LDLR Antibody (SJ0197)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-67414

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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NBP2-67414
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SJ0197

Concentration

1 mg/ml

View all LDLR Antibodies »

Product Summary for LDLR Antibody (SJ0197)

Immunogen

Synthetic peptide within Human LDLR aa 811-860 / 860. (SwissProt: P01130 Human; SwissProt: P35951 Mouse)

Localization

Lysosome, Golgi apparatus, Cell membrane, Early endosome, Late endosome, clathrin-coated pit.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LDLR Antibody (SJ0197)

Western Blot: LDLR Antibody (SJ0197) [NBP2-67414]

Western Blot: LDLR Antibody (SJ0197) [NBP2-67414]

Western Blot: LDLR Antibody (SJ0197) [NBP2-67414] - Analysis of LDL Receptor on MCF-7 lysates using anti-LDL Receptor antibody at 1/1,000 dilution.
Immunocytochemistry/ Immunofluorescence: LDLR Antibody (SJ0197) [NBP2-67414]

Immunocytochemistry/ Immunofluorescence: LDLR Antibody (SJ0197) [NBP2-67414]

Immunocytochemistry/Immunofluorescence: LDLR Antibody (SJ0197) [NBP2-67414] - Staining LDL Receptor in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Immunohistochemistry-Paraffin: LDLR Antibody (SJ0197) [NBP2-67414]

Immunohistochemistry-Paraffin: LDLR Antibody (SJ0197) [NBP2-67414]

Immunohistochemistry-Paraffin: LDLR Antibody (SJ0197) [NBP2-67414] - Analysis of paraffin-embedded human lung tissue using anti-LDL Receptor antibody. Counter stained with hematoxylin.
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Applications for LDLR Antibody (SJ0197)

Application
Recommended Usage

Flow Cytometry

1:50-1:100

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry-Paraffin

1:50-1:200

Western Blot

1:1000-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

TBS (pH7.4), 0.05% BSA, 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LDLR

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis. Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits. It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) were shown to be mediated by LDL receptors on cultured cells.

Long Name

Low Density Lipoprotein Receptor

Alternate Names

LDL R

Gene Symbol

LDLR

Additional LDLR Products

Product Documents for LDLR Antibody (SJ0197)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LDLR Antibody (SJ0197)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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