Leptin receptor (OB-R) is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and LIF receptor. An OB-R transcript encodes a soluble form of the receptor. The transcript was reported to be expressed predominantly in regions of the hypothalamus previously thought to be important in body weight regulation. OB-R binds leptin with high affinity and is a potent leptin antagonist. Human OB-R encodes a 1 165 amino acid residue precursor protein with a 22 amino acid residue signal peptide, an 816 amino acid residue extracellular domain, a 21 amino acid residue transmembrane domain and a 303 amino acid residue cytoplasmic domain.

Long Name

Leptin Receptor

Alternate Names

B219, CD295, LEPR, LeptinR, OB R

Gene Symbol

LEPR

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Product Documents for Leptin R Antibody (RM0085-9C29) [Janelia Fluor® 549]

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Product Specific Notices for Leptin R Antibody (RM0085-9C29) [Janelia Fluor® 549]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Leptin R Antibody (RM0085-9C29) [Janelia Fluor® 549]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-21725JF549

Key Product Details

Species Reactivity

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Product Specifications

Immunogen

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Applications for Leptin R Antibody (RM0085-9C29) [Janelia Fluor® 549]

Western Blot

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Background: Leptin R