Lgr5/GPR49 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS1236

Novus Biologicals, part of Bio-Techne
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NLS1236
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human, Mouse, Rat

Predicted:

Bovine (95%), Hamster (90%), Primate (95%). Backed by our 100% Guarantee.

Applications

Validated:

Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all Lgr5/GPR49 Antibodies »

Product Specifications

Immunogen

A 20 aa synthetic peptide from 1st cytoplasmic domain of human Lgr5/GPR49.

Epitope

1st cytoplasmic domain

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gibbon (100%), Marmoset (95%), Opossum (85%). Mouse reactivity reported in (PMID: 29966501), Rat reactivity reported in (PMID: 26308208).

Specificity

Human Lgr5/GPR49. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for Lgr5/GPR49 Antibody - BSA Free

Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody - BSA Free [NLS1236]

Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody - BSA Free [NLS1236]

Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody [NLS1236] - Anaysis of Lgr5/GPR49 with Brain, hippocampus
Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody - BSA Free [NLS1236]

Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody - BSA Free [NLS1236]

Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody [NLS1236] - Analysis of anti-GPR49 antibody with human, small intestine.
Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody - BSA Free [NLS1236]

Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody - BSA Free [NLS1236]

Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody [NLS1236] - Analysis of anti-GPR49 antibody with human colon.
View 3 more images

Applications for Lgr5/GPR49 Antibody - BSA Free

Application
Recommended Usage

Immunofluorescence

1:10 - 1:500

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS and 10% Glycerol

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: Lgr5/GPR49

GPR49 is an Orphan-A GPCR with an unknown ligand. G protein-coupled receptor GPR49 has been reported to be expressed in brain, skeletal muscle, placenta, and spinal cord. Recent evidence suggests that GPR49 may be involved in the proliferation of cancer cells. GPR49 is over-expressed in both ovarian and colon primary tumors as well as in basal cell carcinomas. Over-expression of GPR49 increases cell proliferation in a human keratinocyte cell line and conveys the ability to form tumors when transplanted into immunodeficient mice. GPR49 appears to act downstream of HedgeHog (Hh) signaling and may be responsible for increased cell proliferation and tumor formation in several types of cancer.

Long Name

Leucine-rich Repeat Containing G Protein-coupled Receptor 5

Alternate Names

FEX, GPR49, GPR67, HG38

Entrez Gene IDs

8549 (Human); 14160 (Mouse); 299802 (Rat)

Gene Symbol

LGR5

Additional Lgr5/GPR49 Products

Product Documents for Lgr5/GPR49 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Lgr5/GPR49 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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