LRP-6 [p Ser1490] Antibody (SR1321)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22610

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1321

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all LRP-6 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-LRP-6 [Ser1490] (Uniprot #: O75581)

Modification

p Ser 1490

Specificity

Detects endogenous levels of total phospho-LRP-6 [Ser1490]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LRP-6 [p Ser1490] Antibody (SR1321)

Western Blot: LRP-6 [p Ser 1490] Antibody (SR1321) [NBP3-22610] -

Western Blot: LRP-6 [p Ser 1490] Antibody (SR1321) [NBP3-22610] - Western blot analysis using NBP3-22610 in HeLa treated with Calyculin cell lysate.

Applications for LRP-6 [p Ser1490] Antibody (SR1321)

Application
Recommended Usage

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LRP-6

Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot (see Application Notes below). However no additional claims are made for their ability to recognise native protein in any application. LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

Long Name

LDL Receptor-related Protein 6

Alternate Names

ADCAD2, FLJ90062, FLJ90421, LRP6

Gene Symbol

LRP6

Additional LRP-6 Products

Product Documents for LRP-6 [p Ser1490] Antibody (SR1321)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LRP-6 [p Ser1490] Antibody (SR1321)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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