LRRFIP2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27199

Novus Biologicals, part of Bio-Techne
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NBP2-27199
NBP2-27199SS
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Key Product Details

Species Reactivity

Human, Equine, Primate

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all LRRFIP2 Antibodies »

Product Specifications

Immunogen

Partial synthetic peptide between amino acids 150-210 of human LRRFIP2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LRRFIP2 Antibody

Immunohistochemistry-Paraffin: LRRFIP2 Antibody [NBP2-27199]

Immunohistochemistry-Paraffin: LRRFIP2 Antibody [NBP2-27199]

Immunohistochemistry-Paraffin: LRRFIP2 Antibody [NBP2-27199] - analysis of LRRFIP2 in formalin-fixed, paraffin-embedded human colon tissue using this antibody at 5 ug/ml.

Applications for LRRFIP2 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LRRFIP2

Leucine-rich repeat flightless-interacting protein 2 (LRRFIP2) belongs to the LRRFIP family. LRRFIP2 has multifaceted functions in innate immunity, apoptosis and development. LRRFIP2 can bind to MyD88 and positively regulate TLR activity as measured by NF-kB activity and cytokine production in macrophages. LPS stimulation also increases LRRFIP2 expression in macrophages. By interacting with Dvl, LRRFIP2 increases the cellular levels of Beta -catenin and activate Beta -catenin/LEF/TCF-dependent transcriptional activity. A dominant negative form of LRRFIP2 suppresses ectopic Wnt signaling in Xenopus embryos and partially inhibits endogenous dorsal axis formation. LRRFIP2 also interacts with Caspase-11 through Flightless-I protein and may be involved in the regulation of proinflammatory caspases by selectively modulating intracellular localization and caspase activity.

Alternate Names

DKFZp434H2035, FLJ20248, FLJ22683, FLJ58304, HUFI-2, leucine rich repeat (in FLII) interacting protein 2, leucine-rich repeat flightless-interacting protein 2, LRR FLII-interacting protein 2

Gene Symbol

LRRFIP2

UniProt

Q9Y608 (Human)

Additional LRRFIP2 Products

Product Documents for LRRFIP2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LRRFIP2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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