LRRK2 Antibody (SR1451)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21641

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21641-100ul
NBP3-21641-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1451

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all LRRK2 Antibodies »

Product Summary for LRRK2 Antibody (SR1451)

Immunogen

A synthesized peptide derived from human LRRK2 (Uniprot #: Q5S007)

Specificity

Detects endogenous levels of total LRRK2

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

286 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for LRRK2 Antibody (SR1451)

Western Blot: LRRK2 Antibody (SR1451) [NBP3-21641] -

Western Blot: LRRK2 Antibody (SR1451) [NBP3-21641] - Western blot analysis using NBP3-21641 in GFP-LRRK2 lysate.

Applications for LRRK2 Antibody (SR1451)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LRRK2

LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

LRRK2 antibodies are useful tools for neurodegeneration research and certian kinase signaling pathway studies.

Long Name

Leucine-rich Repeat Ser/Thr Protein Kinase 2

Alternate Names

AURA17, Dardarin, PARK8, ROCO2

Gene Symbol

LRRK2

Additional LRRK2 Products

Product Documents for LRRK2 Antibody (SR1451)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LRRK2 Antibody (SR1451)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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