Lysine (K)-specific Demethylase 4C/KDM4C/JMJD2C Antibody [FITC]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-49600F

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP1-49600AF350

Alexa Fluor 405

NBP1-49600AF405

Alexa Fluor 488

NBP1-49600AF488

Alexa Fluor 532

NBP1-49600AF532

Alexa Fluor 594

NBP1-49600AF594

Alexa Fluor 647

NBP1-49600AF647

Alexa Fluor 700

NBP1-49600AF700

Alexa Fluor 750

NBP1-49600AF750

Allophycocyanin

NBP1-49600APC

Biotin

NBP1-49600B

CoraFluor 1

NBP1-49600CL1

DyLight 350

NBP1-49600UV

DyLight 405

NBP1-49600V

DyLight 488

NBP1-49600G

DyLight 550

NBP1-49600R

DyLight 594

NBP1-49600DL594

DyLight 650

NBP1-49600C

DyLight 680

NBP1-49600FR

DyLight 755

NBP1-49600IR

HRP

NBP1-49600H

Janelia Fluor 525

NBP1-49600JF525

Janelia Fluor 549

NBP1-49600JF549

Janelia Fluor 585

NBP1-49600JF585

Janelia Fluor 635

NBP1-49600JF635

Janelia Fluor 646

NBP1-49600JF646

Janelia Fluor 669

NBP1-49600JF669

mFluor Violet 450 SE

NBP1-49600MFV450

mFluor Violet 500 SE

NBP1-49600MFV500

mFluor Violet 610 SE

NBP1-49600MFV610

PE

NBP1-49600PE

PerCP

NBP1-49600PCP

Forumulation

Catalog #

BSA Free

NBP1-49600

Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Simple Western, Western Blot

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Lysine (K)-specific Demethylase 4C/KDM4C Antibodies »

Product Summary for Lysine (K)-specific Demethylase 4C/KDM4C/JMJD2C Antibody [FITC]

Immunogen

A partial recombinant protein made to an internal region of the human JMJD2C protein (within residues 450-600). [Swiss-Prot Q9H3R0]

Localization

Nucleus

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Lysine (K)-specific Demethylase 4C/KDM4C/JMJD2C Antibody [FITC]

Application

Recommended Usage

Chromatin Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Chromatin Immunoprecipitation (ChIP)

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Simple Western

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Lysine (K)-specific Demethylase 4C/KDM4C

JMJD2C (Jumonji C domain-containing oxygenase D2C; also called GASC1, JHDM3C or KDM4C) belongs to JMJD2 family and is a histone demethylase for di- and trimethylated lysine 9 and 36 on histone H3 (H3K9me3/2 and H3K36me3/2). H3K9me3/2 is generally associated with transcriptional repression and heterochromatin formation, whereas, H3K36me3/2 is linked to transcriptionaly active genes where it plays a key role in suppression of incorrect transcription. JMJD2C regulates the expression of pluripotency genes including NOTCH1, NANOG, Sox2 and Pou5, and because of its dual role in modifying H3 either by removing the repressive H3K9me3/2 or the active H3K36me3/2 factor, JMJD2C has been considered a fine-tuning regulator of gene expression in normal development/differentiation as well as in carcinogenic progression. JMJD2C is overexpressed in aggressive, basal-like breast cancers compared with non basal-like breast cancers, and its overexpression has been shown to cause transformation of immortalized, non-transformed mammary epithelial cells and to regulate expression of genes responsible for stem cell phenotype/self-renewal in breast cancer cells. Moreover oncogenic role of JMJD2C has been documented in prostate cancer where it enhances the transcription of AR-dependent genes and cell proliferation by interaction with ligand-bound AR.

Alternate Names

GASC1, JHDM3C, JMJD2C, KDM4C, Lysine (K)specific Demethylase 4C

Gene Symbol

KDM4C

Additional Lysine (K)-specific Demethylase 4C/KDM4C Products

Product Documents for Lysine (K)-specific Demethylase 4C/KDM4C/JMJD2C Antibody [FITC]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for Lysine (K)-specific Demethylase 4C/KDM4C/JMJD2C Antibody [FITC]

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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