M-CSFR/CD115 Antibody (12-3A3-1B10) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-43362

Clone 12-3A3-1B10 was used by HLDA to establish CD designation.
Novus Biologicals, part of Bio-Techne
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NBP1-43362-0.1mg
NBP1-43362-25ug
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2a Kappa Clone # 12-3A3-1B10

Format

BSA Free

Concentration

0.5 mg/ml

View all M-CSF R/CD115 Antibodies »

Product Specifications

Immunogen

The immunogen for this antibody was CD115.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2a Kappa

Scientific Data Images for M-CSFR/CD115 Antibody (12-3A3-1B10) - BSA Free

Flow Cytometry: M-CSFR/CD115 Antibody (12-3A3-1B10) - BSA Free [NBP1-43362]

Flow Cytometry: M-CSFR/CD115 Antibody (12-3A3-1B10) - BSA Free [NBP1-43362]

Flow Cytometry: M-CSF R/CD115 Antibody (12-3A3-1B10) [NBP1-43362] - Analysis using the Biotin conjugate of NBP1-43362. Staining of normal human peripheral blood cells with 0.06 ug of Rat IgG2b K Isotype Control Biotin (open histogram) or 0.06 ug of Anti-Human CD115 (c-fms) Biotin (filled histogram) followed by Streptavidin PE.

Applications for M-CSFR/CD115 Antibody (12-3A3-1B10) - BSA Free

Application
Recommended Usage

Flow Cytometry

1:10-1:1000

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Immunoprecipitation

1:10-1:500

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS (pH 7.2)

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: M-CSF R/CD115

CD115 or Colony-Stimulating Factor-1 Receptor (CSF-1R) is expressed on cells committed to the monocyte lineage and osteoclasts. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subsequently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. CSF-1R activation promotes the survival, proliferation and differentiation of mononuclear phagocytes and the spreading and motility of macrophages. In osteoclasts, CSF-1R synergizes with RANKL to regulate the differentiation of mononuclear phagocytes to osteoclasts.

Long Name

Macrophage Colony Stimulating Factor Receptor

Alternate Names

c-fms, CD115, CSF1R, M-CSFR, MCSFR

Gene Symbol

CSF1R

Additional M-CSF R/CD115 Products

Product Documents for M-CSFR/CD115 Antibody (12-3A3-1B10) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for M-CSFR/CD115 Antibody (12-3A3-1B10) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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