MALT1 Antibody (SR2293)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21836

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21836-100ul
NBP3-21836-50ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2293

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MALT1 Antibodies »

Product Summary for MALT1 Antibody (SR2293)

Immunogen

A synthesized peptide derived from human MALT1 (Uniprot #: Q9UDY8)

Specificity

Detects endogenous levels of total MALT1

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

92 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for MALT1 Antibody (SR2293)

Western Blot: MALT1 Antibody (SR2293) [NBP3-21836] -

Western Blot: MALT1 Antibody (SR2293) [NBP3-21836] - Western blot analysis using NBP3-21836 in Jurkat cell lysate.

Applications for MALT1 Antibody (SR2293)

Application
Recommended Usage

Flow Cytometry

1:60

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MALT1

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 (cIAP2/HIAP1) (5).

Long Name

Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1

Alternate Names

MLT1, Paracaspase

Gene Symbol

MALT1

Additional MALT1 Products

Product Documents for MALT1 Antibody (SR2293)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MALT1 Antibody (SR2293)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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