MALT1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24732

Novus Biologicals, part of Bio-Techne
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NBP2-24732
NBP2-24732SS
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all MALT1 Antibodies »

Product Summary for MALT1 Antibody

Immunogen

A synthetic peptide corresponding to amino acids 43-57 ELLDQAPEGRGWRRL of human MALT1 (GenBank No. NP_776216.1) was used as immunogen. The immunogen sequence is 100% conserved between Malt1 isoforms a and b.

Specificity

The antibody was tested on a cell line transfected with full-length SARS Nucleocapsid cDNA with a predicted molecular weight 46 kDa.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MALT1 Antibody

Western Blot: MALT1 Antibody [NBP2-24732]

Western Blot: MALT1 Antibody [NBP2-24732]

Western Blot: MALT1 Antibody [NBP2-24732] - Western bot analysis of MALT1 in Jurkat cell lysate using NBP2-24732 at 0.5 ug/ml.

Applications for MALT1 Antibody

Application
Recommended Usage

Western Blot

0.5-2 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 ml PBS and 0.2% Gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MALT1

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 (cIAP2/HIAP1) (5).

Long Name

Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1

Alternate Names

MLT1, Paracaspase

Gene Symbol

MALT1

UniProt

Q9UDY8 (Human)

Additional MALT1 Products

Product Documents for MALT1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MALT1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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