MAP1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76453

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all MAP1 Antibodies »

Product Summary for MAP1 Antibody - BSA Free

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide from near the center of human MAP-1. The immunogen is located within the last 50 amino acids of MAP1. Amino Acid Squence: CKDYEAAEEEEALLQA

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MAP1 Antibody - BSA Free

Western Blot: MAP1 AntibodyBSA Free [NBP1-76453]

Western Blot: MAP1 AntibodyBSA Free [NBP1-76453]

Western Blot: MAP1 Antibody [NBP1-76453] - Analysis of MAP1 in EL4 cell lysate using NBP1-76453 at (A) 1, (B) 2, and (C) 4 ug/ml.

Applications for MAP1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1-4 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MAP1

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.

Alternate Names

MAP1, MAP-1PNMA4Paraneoplastic antigen Ma4, modulator of apoptosis 1, paraneoplastic antigen like 4

Gene Symbol

MOAP1

UniProt

NP_071434 (Human)

Additional MAP1 Products

Product Documents for MAP1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MAP1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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