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MASP2 Antibody (narsoplimab)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28061

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
Catalog #
Availability
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Qty
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NBP3-28061-100ug
NBP3-28061-50ug

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG4 Clone # narsoplimab

Concentration

LYOPH mg/ml

Product Specifications

Immunogen

MASP2

Clonality

Monoclonal

Host

Human

Isotype

IgG4

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG4SP, and the light chain type is hulambda. It has a predicted MW of 145.5 kDa.

Also known as 'narsoplimab'.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for MASP2 Antibody (narsoplimab)

MASP2 Antibody (narsoplimab)

Functional: MASP2 Antibody (narsoplimab)[NBP3-28061] -

Narsoplimab block C4b production,IC50=0.91 ug/mL.
MASP2 Antibody (narsoplimab)

Functional: MASP2 Antibody (narsoplimab)[NBP3-28061] -

C5b-C9 of the MBL pathway can be completely inhibited by MASP2 Antibody (narsoplimab) with an IC50 of 0.7337 ug/mL.
MASP2 Antibody (narsoplimab)

ELISA: MASP2 Antibody (narsoplimab)[NBP3-28061] -

Immobilized human MASP 2A His at 2 ug/mL can bind MASP2 Antibody (narsoplimab), EC50=0.006278 ug/mL.

Applications for MASP2 Antibody (narsoplimab)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: MASP2

The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases. [provided by RefSeq]

Alternate Names

EC 3.4.21, EC 3.4.21.104, mannan-binding lectin serine peptidase 1 pseudogene 1, mannan-binding lectin serine peptidase 2, mannan-binding lectin serine protease 1 pseudogene 1, mannan-binding lectin serine protease 2, Mannose-binding protein-associated serine protease 2, MAP19, MASP1P1, MASP-2, MBL-associated plasma protein of 19 kD, MBL-associated serine protease 2, small MBL-associated protein, sMAP

Gene Symbol

MASP2

UniProt

Additional MASP2 Products

Product Documents for MASP2 Antibody (narsoplimab)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for MASP2 Antibody (narsoplimab)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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