Mast Cell Protease-1/Mcpt1 Antibody [DyLight 350]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-98243UV

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Mouse

Applications

ELISA

Label

DyLight 350 (Excitation = 353 nm, Emission = 432 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Mast Cell Protease-1/Mcpt1 Antibodies »

Product Specifications

Immunogen

Produced in rabbits immunized with purified, recombinant Mouse Mast Cell Protease-1/Mcpt1 (Accession#: NP_032596.1; Met 1-Lys 246)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Mast Cell Protease-1/Mcpt1 Antibody [DyLight 350]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen and protein A Affinity-purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Mast Cell Protease-1/Mcpt1

Mast cell protease-1 (Mcpt1), also known as beta-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. mMcpt1 is a mast cell protease predominantly expressed in intestinal mucosal mast cells where it promotes mucosal permeability in intestinal allergic hypersensitivity reactions. Its activation is completed by the removal of a two residue N-terminal propeptide by a dipeptidyl peptidase (Cathepsin C). Like human alpha-Chymase, Mcpt1 is capable of the conversion of angiotensin I to angiotensin II, which plays a key role in the regulation of arterial pressure. Studies have shown that specific chymase inhibitors are able to diminish the development of abdominal aortic aneurysm and reduce the adhesion formation after cardiac surgery in hamsters. Therefore, the development of specific inhibitors of chymase activity has been a pharmacologic strategy to develop therapeutic agents.

Alternate Names

Mast Cell Protease1, Mcp1, MMPC-1

Gene Symbol

Mcpt1

Additional Mast Cell Protease-1/Mcpt1 Products

Product Documents for Mast Cell Protease-1/Mcpt1 Antibody [DyLight 350]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Mast Cell Protease-1/Mcpt1 Antibody [DyLight 350]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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