MAVS Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38613

Novus Biologicals, part of Bio-Techne
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NBP2-38613
NBP2-38613-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all MAVS Antibodies »

Product Summary for MAVS Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: PVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MAVS Antibody

Immunohistochemistry-Paraffin: MAVS Antibody [NBP2-38613]

Immunohistochemistry-Paraffin: MAVS Antibody [NBP2-38613]

Immunohistochemistry-Paraffin: MAVS Antibody [NBP2-38613] - Staining of human liver shows low expression as expected.
Immunohistochemistry-Paraffin: MAVS Antibody [NBP2-38613]

Immunohistochemistry-Paraffin: MAVS Antibody [NBP2-38613]

Immunohistochemistry-Paraffin: MAVS Antibody [NBP2-38613] - Staining of human rectum shows high expression.
Immunohistochemistry-Paraffin: MAVS Antibody [NBP2-38613]

Immunohistochemistry-Paraffin: MAVS Antibody [NBP2-38613]

Immunohistochemistry-Paraffin: MAVS Antibody [NBP2-38613] - Staining in human rectum and liver tissues using anti-MAVS antibody. Corresponding MAVS RNA-seq data are presented for the same tissues.
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Applications for MAVS Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MAVS

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).[supplied by OMIM]

Long Name

Mitochondrial Antiviral Signaling Protein

Alternate Names

Cardif, IPS-1, VISA

Gene Symbol

MAVS

UniProt

Q7Z434

Additional MAVS Products

Product Documents for MAVS Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MAVS Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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