MBD2 Antibody (SR1478)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21856

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21856-100ul
NBP3-21856-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1478

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MBD2 Antibodies »

Product Summary for MBD2 Antibody (SR1478)

Immunogen

A synthesized peptide derived from human MBD2 (Uniprot #: Q9UBB5)

Specificity

Detects endogenous levels of total MBD2

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MBD2 Antibody (SR1478)

Western Blot: MBD2 Antibody (SR1478) [NBP3-21856] -

Western Blot: MBD2 Antibody (SR1478) [NBP3-21856] - Western blot analysis using NBP3-21856 in A375 cell lysate.

Applications for MBD2 Antibody (SR1478)

Application
Recommended Usage

Flow Cytometry

1:50

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Immunoprecipitation

1:50

Western Blot

1:5000-1:10000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MBD2

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq]

Long Name

Methyl-CpG-binding domain protein 2

Alternate Names

Demethylase, DMTase

Gene Symbol

MBD2

Additional MBD2 Products

Product Documents for MBD2 Antibody (SR1478)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MBD2 Antibody (SR1478)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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