MBD2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18692

Novus Biologicals, part of Bio-Techne
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NBP3-18692-25ul
NBP3-18692-50ug
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

1.2 mg/ml

View all MBD2 Antibodies »

Product Summary for MBD2 Antibody

Immunogen

Polyclonal antibody raised in rabbit against mouse MBD2 (methyl-CpG binding domain protein 2), using a recombinant protein.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for MBD2 Antibody

Western Blot: MBD2 Antibody [NBP3-18692]

Western Blot: MBD2 Antibody [NBP3-18692]

Western Blot: MBD2 Antibody [NBP3-18692] - Figure 1. Western blot analysis using the antibody directed against MBD2 Whole cell extracts (40 ug) from HeLa cells, transfected with a TY1-tagged MBD2 (lane 2) or an untransfected negative control (lane 1) were analysed by western blot using the antibody against MBD2 diluted 1:1,000 in TBS-Tween containing 5% skimmed milk. The position of the TY1-tagged MBD2 protein is indicated on the right; the marker (in kDa) is shown on the left.

Applications for MBD2 Antibody

Application
Recommended Usage

Western Blot

1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide and 0.05% ProClin 300

Concentration

1.2 mg/ml

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.

Background: MBD2

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq]

Long Name

Methyl-CpG-binding domain protein 2

Alternate Names

Demethylase, DMTase

Gene Symbol

MBD2

UniProt

Q9UBB5 (Human)

Additional MBD2 Products

Product Documents for MBD2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for MBD2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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