MDM2/HDM2 Antibody (MDM2/7061R) [DyLight 488]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14119G

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Product Datasheet / COA / SDS

Recombinant Monoclonal Antibody

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP3-13966

Alexa Fluor 350

NBP3-14119AF350

Alexa Fluor 405

NBP3-14119AF405

Alexa Fluor 488

NBP3-14119AF488

Alexa Fluor 532

NBP3-14119AF532

Alexa Fluor 594

NBP3-14119AF594

Alexa Fluor 647

NBP3-14119AF647

Alexa Fluor 700

NBP3-14119AF700

Alexa Fluor 750

NBP3-14119AF750

Allophycocyanin

NBP3-14119APC

Biotin

NBP3-14119B

CoraFluor 1

NBP3-14119CL1

DyLight 350

NBP3-14119UV

DyLight 405

NBP3-14119V

DyLight 550

NBP3-14119R

DyLight 594

NBP3-14119DL594

DyLight 650

NBP3-14119C

DyLight 680

NBP3-14119FR

DyLight 755

NBP3-14119IR

FITC

NBP3-14119F

HRP

NBP3-14119H

Janelia Fluor 525

NBP3-14119JF525

Janelia Fluor 549

NBP3-14119JF549

Janelia Fluor 585

NBP3-14119JF585

Janelia Fluor 635

NBP3-14119JF635

Janelia Fluor 646

NBP3-14119JF646

Janelia Fluor 669

NBP3-14119JF669

PE

NBP3-14119PE

PerCP

NBP3-14119PCP

Forumulation

Catalog #

Azide and BSA Free

NBP3-14119

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

ELISA

Label

DyLight 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Rabbit IgG Clone # MDM2/7061R

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MDM2/HDM2 Antibodies »

Product Specifications

Immunogen

Recombinant human MDM2/HDM2 protein fragment (around aa 126-254) (exact sequence is proprietary) (Uniprot: Q00987)

Reactivity Notes

0

Localization

Nuclear

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications for MDM2/HDM2 Antibody (MDM2/7061R) [DyLight 488]

Application

Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: MDM2/HDM2

MDM2 is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Long Name

Double Minute 2 Protein

Alternate Names

HDM2

Gene Symbol

MDM2

Additional MDM2/HDM2 Products

Product Documents for MDM2/HDM2 Antibody (MDM2/7061R) [DyLight 488]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for MDM2/HDM2 Antibody (MDM2/7061R) [DyLight 488]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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