MDM2/HDM2 Antibody (MDM2/7189R) [DyLight 550]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21097R

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Product Datasheet / COA / SDS

Recombinant Monoclonal Antibody

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP3-20440

Alexa Fluor 350

NBP3-21097AF350

Alexa Fluor 405

NBP3-21097AF405

Alexa Fluor 488

NBP3-21097AF488

Alexa Fluor 532

NBP3-21097AF532

Alexa Fluor 594

NBP3-21097AF594

Alexa Fluor 647

NBP3-21097AF647

Alexa Fluor 700

NBP3-21097AF700

Alexa Fluor 750

NBP3-21097AF750

Allophycocyanin

NBP3-21097APC

Biotin

NBP3-21097B

CoraFluor 1

NBP3-21097CL1

DyLight 350

NBP3-21097UV

DyLight 405

NBP3-21097V

DyLight 488

NBP3-21097G

DyLight 594

NBP3-21097DL594

DyLight 650

NBP3-21097C

DyLight 680

NBP3-21097FR

DyLight 755

NBP3-21097IR

FITC

NBP3-21097F

HRP

NBP3-21097H

Janelia Fluor 525

NBP3-21097JF525

Janelia Fluor 549

NBP3-21097JF549

Janelia Fluor 585

NBP3-21097JF585

Janelia Fluor 635

NBP3-21097JF635

Janelia Fluor 646

NBP3-21097JF646

Janelia Fluor 669

NBP3-21097JF669

PE

NBP3-21097PE

PerCP

NBP3-21097PCP

Forumulation

Catalog #

Azide and BSA Free

NBP3-21097

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

DyLight 550 (Excitation = 562 nm, Emission = 576 nm)

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # MDM2/7189R

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MDM2/HDM2 Antibodies »

Product Specifications

Immunogen

Recombinant human MDM2/HDM2 protein fragment (exact sequence is proprietary)

Localization

Nucleus.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Applications for MDM2/HDM2 Antibody (MDM2/7189R) [DyLight 550]

Application

Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: MDM2/HDM2

MDM2 is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Long Name

Double Minute 2 Protein

Alternate Names

HDM2

Gene Symbol

MDM2

Additional MDM2/HDM2 Products

Product Documents for MDM2/HDM2 Antibody (MDM2/7189R) [DyLight 550]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for MDM2/HDM2 Antibody (MDM2/7189R) [DyLight 550]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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