Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all MEL-18 Antibodies »

Product Summary for MEL-18 Antibody

Immunogen

The immunogen recognized by this antibody maps to a region between residue 125 and 175 of human DNA-binding Protein Mel-18 using the numbering given in entry NP_009075.1 (GeneID 7703).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MEL-18 Antibody

Western Blot: MEL-18 Antibody [NBP2-04032]

Western Blot: MEL-18 Antibody [NBP2-04032]

Western Blot: MEL-18 Antibody [NBP2-04032] - Whole cell lysate from HeLa (15 and 50 ug), 293T (T; 50 ug) and Jurkat (J; 50 ug) cells. Antibody used at 0.1 ug/ml.

Applications for MEL-18 Antibody

Application
Recommended Usage

Western Blot

1:2000-1:10000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: MEL-18

MEL-18 is a transcriptional repressor that binds specifically to the DNA sequence 5'-GACTNGACT-3'. Mel18 has tumor suppressor activity and may play a role in cell proliferation and/or neural cell development. It regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells.

Alternate Names

MEL-18, polycomb group ring finger 2, polycomb group RING finger protein 2, RING finger protein 110DNA-binding protein Mel-18, RNF110MEL18, Zinc finger protein 144, ZNF144MGC10545

Entrez Gene IDs

NP_009075.1 (Human)

Gene Symbol

PCGF2

Additional MEL-18 Products

Product Documents for MEL-18 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for MEL-18 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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