Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all MEX3D Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide from near the center of human Rkhd1. The immunogen is located within amino acids 360 - 410 of Rkhd1. Amino Acid Squence: WAKTPNQGRRPPTAT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MEX3D Antibody - BSA Free

Western Blot: MEX3D AntibodyBSA Free [NBP1-77332]

Western Blot: MEX3D AntibodyBSA Free [NBP1-77332]

Western Blot: MEX3D Antibody [NBP1-77332] - MDA-MB-361 cell lysate with MEX3D antibody at (A) 1 ug/ml and (B) 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: MEX3D Antibody - BSA Free [NBP1-77332]

Immunocytochemistry/ Immunofluorescence: MEX3D Antibody - BSA Free [NBP1-77332]

Immunocytochemistry/Immunofluorescence: MEX3D Antibody [NBP1-77332] - Immunofluorescence of rkhd1 in human small intestine tissue with rkhd1 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: MEX3D Antibody - BSA Free [NBP1-77332]

Immunohistochemistry-Paraffin: MEX3D Antibody - BSA Free [NBP1-77332]

Immunohistochemistry-Paraffin: MEX3D Antibody [NBP1-77332] - Human small intestine tissue with MEX3D antibody at 2.5 ug/ml.
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Applications for MEX3D Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MEX3D

Rkhd1, also known as TINO or MEX3D is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd1, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd1 binds to the AU-rich element in the 3'-untranslated region of Bcl-2 mRNA and is thought to be a negative regulator of Bcl-2 expression. Rkhd3 and Rkhd4, but not Rkhd1, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.

Alternate Names

KIAA2031Tino, mex-3 homolog D (C. elegans), OK/SW-cl.4, ring finger (C3HC4 type) and KH domain containing 1, ring finger and KH domain containing 1, RING finger and KH domain-containing protein 1, RING finger protein 193, RKHD1MEX3, RNA-binding protein MEX3D, RNF193MEX-3D, TINObcl-2 ARE RNA binding protein

Gene Symbol

MEX3D

UniProt

Q86XN8 (Human)

Additional MEX3D Products

Product Documents for MEX3D Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for MEX3D Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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