mGluR2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-68855

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Rabbit (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all mGluR2 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-KETAPERREV corresponding to internal region according to NP_001123535.1.

Epitope

C-KETAPERREV

Specificity

This antibody is expected to recognize both isoforms (NP_000830.2; NP_001123535.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for mGluR2 Antibody

Western Blot: mGluR2 Antibody [NBP1-68855]

Western Blot: mGluR2 Antibody [NBP1-68855]

Western Blot: mGluR2 Antibody [NBP1-68855] - Analysis of metabotropic Glutamate Receptor 2 in Human Hippocampus lysate (35ug protein in RIPA buffer) using NBP1-68855 at 1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: mGluR2 Antibody [NBP1-68855]

Immunohistochemistry-Paraffin: mGluR2 Antibody [NBP1-68855]

Immunohistochemistry-Paraffin: mGluR2 Antibody [NBP1-68855] - Staining of paraffin embedded Human Cerebral Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for mGluR2 Antibody

Application
Recommended Usage

Immunohistochemistry

3 - 5 ug/ml

Immunohistochemistry-Paraffin

3 - 5 ug/ml

Peptide ELISA

Detection limit 1:16000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 30 kDa band observed in human brain (hippocampus) lysates (calculated MW of 27.5 kDa band according to NP_001123535.1). IHC-P: Human cerebral cortex shows membranous/axonal staining.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: mGluR2

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Long Name

Metabotropic Glutamate Receptor 2

Alternate Names

GPRC1B, GRM2, mGluR7

Entrez Gene IDs

2912 (Human); 108068 (Mouse); 24415 (Rat)

Gene Symbol

GRM2

UniProt

NP_000830.2 (Human)

Additional mGluR2 Products

Product Documents for mGluR2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for mGluR2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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