mGluR7 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-26397

Novus Biologicals, part of Bio-Techne
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NBP1-26397
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all mGluR7 Antibodies »

Product Specifications

Immunogen

Peptide with sequence NCKLTISGSKKEDT corresponding to internal region according to NP_870989.1.

Specificity

This antibody is expected to recognize both reported isoforms (NP_000835.1; NP_870989.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for mGluR7 Antibody

Western Blot: mGluR7 Antibody [NBP1-26397]

Western Blot: mGluR7 Antibody [NBP1-26397]

Western Blot: metabotropic glutamate receptor 7 Antibody [NBP1-26397] - Western Blot: mGluR7 Antibody [NBP1-23025] (0.5ug/ml) staining of Human Cer(35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for mGluR7 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

0.5 - 2 ug/ml
Application Notes
WB: Approx. 100 kDa band observed in human brain (cerebellum) and in mouse and rat brain lysates (calculated MW of 102 kDa band according to NP_000835.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: mGluR7

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Long Name

Metabotropic Glutamate Receptor 7

Alternate Names

GPRC1G, GRM7

Entrez Gene IDs

2917 (Human); 108073 (Mouse); 81672 (Rat)

Gene Symbol

GRM7

UniProt

NP_000835.1 (Human)

Additional mGluR7 Products

Product Documents for mGluR7 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for mGluR7 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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