mGluR7 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS917

Novus Biologicals, part of Bio-Techne
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NLS917
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Bovine, Canine, Equine, Monkey, Primate

Cited:

Human, Rat

Predicted:

Chimpanzee (100%), Orangutan (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all mGluR7 Antibodies »

Product Specifications

Immunogen

Synthetic 20 amino acid peptide from N-terminal extracellular domain of human mGluR7.

Epitope

N-Terminus extracellular domain

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Opossum (80%), Turkey (80%), Chicken (80%).

Localization

Cell membrane; Multi-pass membrane protein.

Specificity

Human mGluR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM4 (60%), GRM6 (45%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for mGluR7 Antibody - BSA Free

Immunohistochemistry-Paraffin: mGluR7 Antibody - BSA Free [NLS917]

Immunohistochemistry-Paraffin: mGluR7 Antibody - BSA Free [NLS917]

Immunohistochemistry-Paraffin: mGluR7 Antibody [NLS917] - Analysis of anti-GRM7 / MGLUR7 antibody with human adrenal at dilution 7 ug/ml.
Immunohistochemistry-Paraffin: mGluR7 Antibody - BSA Free [NLS917]

Immunohistochemistry-Paraffin: mGluR7 Antibody - BSA Free [NLS917]

Immunohistochemistry-Paraffin: mGluR7 Antibody [NLS917] - Analysis of anti-GRM7 / MGLUR7 antibody with human liver at dilution 7 ug/ml.

Applications for mGluR7 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

7 ug/ml

Western Blot

1:1000 - 1:10000
Application Notes
Use in ICC/IF reported in scientific literature (PMID: 24858010)..

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: mGluR7

Metabotropic Glutamate Receptor GRM7 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. GRM7 is highly concentrated at presynaptic terminals and is thought to play an important role in the modulation of glutamatergic synaptic transmission by effecting presynaptic inhibition of glutamate release. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group III includes GRM4, GRM6, GRM7, and GRM8 receptors, which are linked to inhibition of the cyclic AMP signaling cascade. Five mRNA variants of GRM7 have been described; most of the variants are expressed in brain and retina, although there are non-neuronal variants that may have different functional properties. GRM7 has been reported to be expressed in active zones of presynaptic axon terminals in various regions of the brain, eye, and spinal cord. Caution: GLUR7 refers to Ionotropic Glutamate Receptor 7, not to Metabotropic Glutamate Receptor 7 (mGLUR7).

Long Name

Metabotropic Glutamate Receptor 7

Alternate Names

GPRC1G, GRM7

Entrez Gene IDs

2917 (Human)

Gene Symbol

GRM7

Additional mGluR7 Products

Product Documents for mGluR7 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for mGluR7 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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