The MIC gene is located in MHC class I region. MICA/B are 65-75 kD stress-inducible glycoproteins with highly polymorphic. They are MHC class I-like transmembrane molecules that do not associate beta2-microglobulin and do not present peptides. MICA and MICB share 85% identify, and are mainly expressed on Intestinal epithelial cells, epithelial tumor cells, endothelial cells, fibroblasts, and IFN- alpha-stimulated dendritic cells. MIC molecules bind NKG2D, an activating receptor, and induce activation of NK cells, and subset of CD8+ alpha/ beta T cells and gamma/ delta T cells, as well as suppression of T cell proliferation. MICA/B recognition is involved in the regulation of tumor surveillance, viral infection and autoimmune diseases.

Long Name

MHC Class I-related Protein A and B

Alternate Names

MHC class I chain-related protein A, MHC class I chain-related protein B, MIC, MICA, MICB, PERB11, PERB11.1, PERB11.2

Gene Symbol

MICA

Additional MICA/B Products

Product Documents for MICA/B Antibody (159207) [Biotin]

Product Datasheets

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COA

SDS

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Product Specific Notices for MICA/B Antibody (159207) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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MICA/B Antibody (159207) [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # FAB13001B

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

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Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype

Applications for MICA/B Antibody (159207) [Biotin]

Blockade of Receptor-ligand Interaction

CyTOF-ready

Flow Cytometry

Immunohistochemistry

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: MICA/B