Mind Bomb 1/MIB1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85210

Novus Biologicals, part of Bio-Techne
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NBP1-85210
NBP1-85210-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Predicted:

Rat (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Mind Bomb 1/MIB1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: LDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAM

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 30590051).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Mind Bomb 1/MIB1 Antibody

Immunocytochemistry/ Immunofluorescence: Mind Bomb 1/MIB1 Antibody [NBP1-85210]

Immunocytochemistry/ Immunofluorescence: Mind Bomb 1/MIB1 Antibody [NBP1-85210]

Immunocytochemistry/Immunofluorescence: Mind Bomb 1/MIB1 Antibody [NBP1-85210] - Staining of human cell line U-2 OS shows localization to nuclear membrane, plasma membrane & vesicles. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Mind Bomb 1/MIB1 Antibody [NBP1-85210]

Immunohistochemistry-Paraffin: Mind Bomb 1/MIB1 Antibody [NBP1-85210]

Immunohistochemistry-Paraffin: Mind Bomb 1/MIB1 Antibody [NBP1-85210] - Staining of human hippocampus shows moderate cytoplasmic positivity in neuronal cells.

Applications for Mind Bomb 1/MIB1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

Use in WB reported in scientific literature (PMID: 30590051).
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Mind Bomb 1/MIB1

E3 ubiquitin ligase protein mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. It positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

Long Name

Mindbomb Homolog 1

Alternate Names

DIP1, MIB1, ZZANK2

Gene Symbol

MIB1

Additional Mind Bomb 1/MIB1 Products

Product Documents for Mind Bomb 1/MIB1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Mind Bomb 1/MIB1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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