MKRN3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84320

Novus Biologicals, part of Bio-Techne
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NBP1-84320
NBP1-84320-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all MKRN3 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPPAASSLSLPVIGSAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASA

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MKRN3 Antibody

Immunocytochemistry/ Immunofluorescence: MKRN3 Antibody [NBP1-84320]

Immunocytochemistry/ Immunofluorescence: MKRN3 Antibody [NBP1-84320]

Immunocytochemistry/Immunofluorescence: MKRN3 Antibody [NBP1-84320] - Staining of human cell line A-431 shows localization to nucleoplasm, plasma membrane & cytosol. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: MKRN3 Antibody [NBP1-84320]

Immunohistochemistry-Paraffin: MKRN3 Antibody [NBP1-84320]

Immunohistochemistry-Paraffin: MKRN3 Antibody [NBP1-84320] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

Applications for MKRN3 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50-1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MKRN3

MKRN3, also known as Probable E3 ubiquitin-protein ligase makorin-3, is a 507 amino acid protein that is 56 kDa, contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs, and acts as a catalyzer of the covalent attachment of ubiquitin moieties onto substrate proteins. Current research is being performed on this protein involvement in Prader-Willi syndrome, Angelman syndrome, Canavan disease, and intellectual disability. This protein is necessary for protein ubiquitination forming interaction with TSG101, UBE2D2, UBE2D3, UBE2I, UBE2N, UBE2V1, UBE2W, UBE2U, UBE2D1, UBE2D4, UBE2E1, UBE2E2, UBE2H, UBE2K, UBE2L3, UBE2V2, UBE2E3, C11orf57, ENKD1, LRSAM1, MDM2, and over 20 other proteins.

Alternate Names

EC 6.3.2.-, makorin ring finger protein 3, MGC88288, RNF63D15S9, ZFP127RING finger protein 63, Zinc finger protein 127, ZNF127probable E3 ubiquitin-protein ligase makorin-3

Gene Symbol

MKRN3

Additional MKRN3 Products

Product Documents for MKRN3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MKRN3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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