MMP-12 Antibody (706F9.01)

Novus Biologicals, part of Bio-Techne | Catalog # DDX0281P-100

Novus Biologicals, part of Bio-Techne
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DDX0281P-100
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 706F9.01

Concentration

0.5 mg/ml

View all MMP-12 Antibodies »

Product Specifications

Immunogen

MMP-12/HME was used as immunogen.

Reactivity Notes

Human

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for MMP-12 Antibody (706F9.01)

Immunohistochemistry: MMP-12 Antibody (706F9.01) [DDX0281P-100]

Immunohistochemistry: MMP-12 Antibody (706F9.01) [DDX0281P-100]

Immunohistochemistry: MMP-12 Antibody (706F9.01) [DDX0281P-100] - Staining of human tonsil frozen section.
ELISA: MMP-12 Antibody (706F9.01) [DDX0281P-100]

ELISA: MMP-12 Antibody (706F9.01) [DDX0281P-100]

ELISA: MMP-12 Antibody (706F9.01) [DDX0281P-100] - ELISA with 706F9.01/701E4.03 anti-HME 1000 ng/ml1= control2= HME-transfected cells3= CD34++GMCSF+TNF- +IL44= patient serum of Langerhans histiocytosis

Applications for MMP-12 Antibody (706F9.01)

Application
Recommended Usage

Immunoprecipitation

1:10-1:500

Western Blot

1:100-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

Tris-NaCl (pH 8.0)

Preservative

No Preservative

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: MMP-12

Human macrophage elastase (MMP-12) is a member of the family of matrix metalloproteinases (MMPs) that plays, like other members of the family, an important role in inflammatory processes contributing to tissue remodeling and destruction. In particular, a prominent role of MMP-12 in the destruction of elastin in the lung alveolar wall and the pathogenesis of emphysema has been suggested. It is therefore an attractive therapeutic target (1). MMP-12) expressed mainly in alveolar macrophages has been identified in the mouse lung as the main destructive agent associated with cigarette smoking, which gives rise to emphysema, both directly via elastin degradation and indirectly by disturbing the proteinase/antiproteinase balance via inactivation of the alpha1-proteinase inhibitor (alpha1-PI), the antagonist of the leukocyte elastase (2). Because elastin represents a critical component of aortic wall structure and a matrix substrate for metalloelastases, MMP-12 may have a direct and singular role in the pathogenesis of aortic aneurysms (3).

Long Name

Matrix Metalloproteinase 12

Alternate Names

MMP12

Gene Symbol

MMP12

UniProt

NP_002417 (Human)

Additional MMP-12 Products

Product Documents for MMP-12 Antibody (706F9.01)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MMP-12 Antibody (706F9.01)

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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