The matrix metalloproteinase (MMP) family (approximately 25 members in mammals) has been implicated in extracellular matrix remodeling associated with embryonic development, cancer formation and progression, and various other physiological and pathological events. MMP-14 is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating pericellular proteolysis of extracellular matrix components. MMP-14 is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix (1). Gelatinase A (type-IV collagenase; M(r) 72,000) is produced by tumour stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as type IV collagen. MMP-14 may thus trigger invasion by tumor cells by activating pro-gelatinase A on the tumor cell surface (2). Observations identify MT1-MMP as a tumor-derived growth factor that regulates proliferation by controlling cell geometry within the confines of the 3D extracellular matrix (ECM) (3).

Long Name

Matrix Metalloproteinase 14/Membrane Type 1 MMP

Alternate Names

MMP-X1, MMP14, MT-MMP1, MT1-MMP

Gene Symbol

MMP14

Additional MMP-14/MT1-MMP Products

Product Documents for MMP-14/MT1-MMP Antibody (MM0027-9E10) [mFluor Violet 500 SE]

Product Datasheets

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COA

SDS

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Product Specific Notices for MMP-14/MT1-MMP Antibody (MM0027-9E10) [mFluor Violet 500 SE]

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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MMP-14/MT1-MMP Antibody (MM0027-9E10) [mFluor Violet 500 SE]

Novus Biologicals, part of Bio-Techne | Catalog # NB110-60993MFV500

Key Product Details

Species Reactivity

Validated:

Applications

Label

Antibody Source

Concentration

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Product Summary for MMP-14/MT1-MMP Antibody (MM0027-9E10) [mFluor Violet 500 SE]

Immunogen

Localization

Specificity

Clonality

Host

Isotype

Applications for MMP-14/MT1-MMP Antibody (MM0027-9E10) [mFluor Violet 500 SE]

Immunohistochemistry

Immunohistochemistry-Paraffin

Western Blot

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: MMP-14/MT1-MMP