MMP-7 Antibody [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-99123B

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Biotin

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MMP-7 Antibodies »

Product Summary for MMP-7 Antibody [Biotin]

Immunogen

A synthetic peptide made to an internal portion of the human MMP7 protein (between residues 250-300) [UniProt P09237]

Localization

Secreted, extracellular space, extracellular matrix

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for MMP-7 Antibody [Biotin]

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: MMP-7

Matrix Metalloproteinases (MMPs) belong to a family of proteases that are essential for the breakdown of extracellular matrix (ECM). They are important in tumor cell growth, invasion, and metastasis, as well as angiogenesis, wound healing, and apoptosis. Most MMPs contain common domain structures that include a signal sequence, a propeptide, a catalytic domain, and a hemopexin like (Hpx) domain. Matrix metalloproteinase-7 (MMP7), also known as Matrilysin, belongs to the peptidase M10A family, and is responsible for hydrolyzing proteoglycans and ECM glycoproteins. MMP7 will activate procollagenase while degrading gelatin types I, III, IV, and V, and casein. In addition, MMP7 is expressed in normal and cancer cells, specifically glandular epithelial cells and pancreatic carcinoma. Research suggests that MMP7 may play an important role in the early stages of tumor progression.

Long Name

Matrix Metalloproteinase 7

Alternate Names

Matrilysin, MMP7

Gene Symbol

MMP7

Additional MMP-7 Products

Product Documents for MMP-7 Antibody [Biotin]

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MMP-7 Antibody [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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