Mouse ADAM19 Ectodomain Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB1229

R&D Systems, part of Bio-Techne
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MAB1229
MAB1229-SP
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Key Product Details

Species Reactivity

Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2A Clone # 164646

View all ADAM19 Antibodies »

Product Specifications

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse ADAM19 Ectodomain
Asp205-Gly705 (predicted)
Accession # O35674

Specificity

Detects mouse ADAM19 Ectodomain in direct ELISAs and Western blots. It also recognizes a C-terminal fragment (amino acids 588‑705) of recombinant mouse (rm) ADAM19 in Western blots. In Western blots, no cross-reactivity with rmADAM10 or rmADAM15 is observed.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2A

Applications for Mouse ADAM19 Ectodomain Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Mouse ADAM19 Ectodomain
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ADAM19

ADAM19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrin-beta) is a 95‑100 kDa member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. After cleavage of a signal sequence and prodomain, the ectodomain circulates in plasma bound to alpha2-Macroglobulin. ADAM19 cleaves at sequences present in myelin basic protein, insulin beta chain, TNF-alpha, TRANCE and SCF. Over amino acids (aa) 205‑705, mouse ADAM19 shares 87% aa sequence identity with human ADAM19.

Long Name

A Disintegrin and Metalloprotease-like Domain 19

Alternate Names

Meltrin beta

Entrez Gene IDs

8728 (Human); 11492 (Mouse)

Gene Symbol

ADAM19

UniProt

O35674

Additional ADAM19 Products

Product Documents for Mouse ADAM19 Ectodomain Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Mouse ADAM19 Ectodomain Antibody

For research use only

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