Mouse APLP-2 Antibody

R&D Systems, part of Bio-Techne | Catalog # AF3685

R&D Systems, part of Bio-Techne
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AF3685
AF3685-SP
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Key Product Details

Species Reactivity

Validated:

Mouse

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Bioassay, Immunohistochemistry

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

View all APLP-2 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse APLP-2
Leu37-Ser624
Accession # AAH52396.2

Specificity

Detects mouse APLP-2 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) APLP-2 is observed and less than 1% cross-reactivity with rhAPLP-1 and recombinant mouse APLP-1 is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Mouse APLP-2 Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Mouse APLP-2

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: APLP-2

Mouse APLP-2 is a 120-170 kDa (695 aa) member of the APP family of type I transmembrane (TM) proteins. Its 595 aa extracellular region has multiple domains, including an N-terminal Cys-rich domain, an Asp/Glu-rich acidic region, and a membrane proximal linker region that contains a GAG attachment site. Several alternatively spliced APLP-2 isoforms have been reported. APLP-2 is proteolytically cleaved by MMPs and secretases and forms both homodimers and heterodimers with APP and APLP-1. Over the range used as immunogen, mouse APLP-2 shares 97% and 91% aa sequence identity with rat and human ALPL-2, respectively.

Long Name

Amyloid Beta [A4] Precursor-like Protein 2

Alternate Names

APLP2, APPH, APPL2, CDEBP, WALPLP2, YWK-II

Entrez Gene IDs

334 (Human); 11804 (Mouse); 64312 (Rat)

Gene Symbol

APLP2

UniProt

AAH52396.2

Additional APLP-2 Products

Product Documents for Mouse APLP-2 Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Mouse APLP-2 Antibody

For research use only

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