Mouse EPCR Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB27491
Key Product Details
Species Reactivity
Mouse
Applications
Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Rat IgG2B Clone # 432732
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse EPCR
Leu18-Ser214
Accession # Q64695
Leu18-Ser214
Accession # Q64695
Specificity
Detects mouse EPCR in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human EPCR is observed.
Clonality
Monoclonal
Host
Rat
Isotype
IgG2B
Applications for Mouse EPCR Antibody
Application
Recommended Usage
Western Blot
1 µg/mL
Sample: Recombinant Mouse EPCR
Sample: Recombinant Mouse EPCR
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: EPCR
Protein C is a vitamin K-dependent serine protease that plays a major role in blood coagulation. Binding of Protein C to the Endothelial Protein C Receptor (EPCR; gene name Procr) leads to the proteolytic activation of PAR1 (protease-activated receptor 1) on endothelial cells and subsequent up-regulation of Protein C-induced genes. EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology.
Long Name
Endothelial Protein C Receptor
Alternate Names
CCD41, CD201, PROCR
Gene Symbol
PROCR
UniProt
Additional EPCR Products
Product Documents for Mouse EPCR Antibody
Product Specific Notices for Mouse EPCR Antibody
For research use only
Loading...
Loading...
Loading...
Loading...