Mouse IGFALS/ALS Biotinylated Antibody
R&D Systems, part of Bio-Techne | Catalog # BAF1436
Key Product Details
Species Reactivity
Validated:
Mouse
Cited:
Mouse
Applications
Validated:
Western Blot
Cited:
ELISA Development
Label
Biotin
Antibody Source
Polyclonal Goat IgG
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse IGFALS/ALS
Thr28-Cys603
Accession # P70389
Thr28-Cys603
Accession # P70389
Specificity
Detects mouse IGFALS/ALS in Western blots.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications for Mouse IGFALS/ALS Biotinylated Antibody
Application
Recommended Usage
Western Blot
0.1 µg/mL
Sample: Recombinant Mouse IGFALS/ALS
Sample: Recombinant Mouse IGFALS/ALS
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IGFALS/ALS
ALS (Acid labile subunit) is an 84-86 kDa glycoprotein member of the leucine rich repeat superfamily of molecules. It is secreted by hepatocytes in response to growth hormone stimulation, and forms a 140-150 kDa ternary complex with IGFBP3 (or IGFBP5) and IGF-I. This complex increases the half-life of IGF-I and retains it in the circulation for use in multiple tissues. Mature mouse ALS is 580 amino acids (aa) in length (aa 24-603). It contains twenty-one 20-23 aa LRRs that participate in protein-protein interactions. There are two potential isoform variants that show N-terminal extensions. One contains a 66 aa substitution for aa 1-5, while another possesses an 89 aa substitution again for aa 1-5. Over aa 28-603, mouse ALS shares 79% and 93% aa identity with human and rat ALS, respectively.
Long Name
IGF-binding Protein Acid Labile Subunit
Alternate Names
ACLSD, ALS
Gene Symbol
IGFALS
UniProt
Additional IGFALS/ALS Products
Product Documents for Mouse IGFALS/ALS Biotinylated Antibody
Product Specific Notices for Mouse IGFALS/ALS Biotinylated Antibody
For research use only
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