Mouse JMJD6/PSR Antibody

JMJD6 (Jumonji [Japanese for "cruciform/cross"] domain-containing protein 6; also PTDSR/PSR and Lysyl-hydroxylase JMJD6) is a 47-55 kDa member of the JMJD6 family, cupin superfamily of proteins. It is induced by hypoxia, and expressed in skeletal muscle, macrophages and possibly endothelial cells. JMJD6 is reported to demethylate histones (which it does not), serve as a phosphatidyl serine receptor (which it might), and act as a lysyl hydroxylase (which it does). In the nucleus, it appears to regulate pre-RNA splicing by hydroxylating various splicing factors such as U2AF65. Mouse JMJD6 is 403 amino acids (aa) in length. It contains five NLS's plus a JmjC domain (aa 141-305) and three iron-based catalytic sites. There at least three potential isoform variants. One contains a 29 aa substitution for aa 270‑403, a second possesses a 30 aa substitution for aa 302-314, and a third shows a 21 aa substitution for aa 315-403. JMJD6 is known to form high MW homo‑trimers, -tetramers and -oligomers. Full-length mouse JMJD6 shares 98% and 99% aa sequence identity with human and rat JMJD6, respectively.