Mouse Mer APC-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB5912A
Key Product Details
Species Reactivity
Validated:
Cited:
Applications
Validated:
Cited:
Label
Antibody Source
Product Specifications
Immunogen
Glu23-Phe498
Accession # Q60805
Specificity
Clonality
Host
Isotype
Scientific Data Images for Mouse Mer APC-conjugated Antibody
Detection of Mer in J774A.1 Mouse Cell Line by Flow Cytometry.
J774A.1 mouse reticulum cell sarcoma macrophage cell line was stained with Rat Anti-Mouse Mer APC-conjugated Monoclonal Antibody (Catalog # FAB5912A, filled histogram) or isotype control antibody (Catalog # IC006A, open histogram). View our protocol for Staining Membrane-associated Proteins.Applications for Mouse Mer APC-conjugated Antibody
Flow Cytometry
Sample: J774A.1 mouse reticulum cell sarcoma macrophage cell line
Reviewed Applications
Read 3 reviews rated 4.7 using FAB5912A in the following applications:
Formulation, Preparation, and Storage
Purification
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Mer
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein Growth-Arrest-Specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions (1-2).
References
- Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
- Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.
Long Name
Alternate Names
Gene Symbol
UniProt
Additional Mer Products
Product Documents for Mouse Mer APC-conjugated Antibody
Product Specific Notices for Mouse Mer APC-conjugated Antibody
For research use only