Mouse Prostasin/Prss8 Antibody

Prostasin encoded by the Prss8 gene, also known as channel activating protease 1, is a serine protease with a trypsin-like substrate specificity (1, 2). The preproenzyme possesses a C-terminal membrane-spanning domain that can be proteolytically processed to generate a secreted form of the enzyme. The secreted form of prostasin has been purified from seminal fluid (2). Prostasin is highly expressed in the prostate gland, and is expressed at lower levels in the lung, kidney, liver, salivary gland, and pancreas (3). The peptidase activity of prostasin is involved in the regulation of epithelial sodium channels (4, 5). The enzymatic activity of Prostasin is effectively inhibited by HAI-1 and HAI-2B (Catalog # http://www.rndsystems.com/product_results.aspx?k=1141-PI">1141-PI and http://www.rndsystems.com/product_results.aspx?k=1107-PI">1107-PI).